Unexplained fatigue, weight loss, or recurrent infections? Serum Protein Electrophoresis (SPEP) could be the key to uncovering serious conditions like multiple myeloma, chronic infections, or autoimmune diseases.

But when should we order it, and how do we interpret tricky results of SPEP?

This article simplifies SPEP, breaks down immunofixation and immunofluorescence, and provides a practical roadmap for us to make informed, evidence-based decisions in primary care.

We review diagnostic pearls for thalassemia, including use of the CBC, iron studies, peripheral blood smear, and hemoglobin electrophoresis

Read time: 6-7 minutes